1001 Décarie, CHHD Mail Drop Point #EM03211 (Cubicle C), Montreal, QC H4A 3J1, CA
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    • Home
    • Our Research
    • Our Team
      • Dr. Geneviève Bernard
      • Lab Members
    • Publications
    • Partnerships
      • Funding
      • Collaborators
    • Highlights
    • Resources
    • Contact Us
  • Home
  • Our Research
  • Our Team
    • Dr. Geneviève Bernard
    • Lab Members
  • Publications
  • Partnerships
    • Funding
    • Collaborators
  • Highlights
  • Resources
  • Contact Us

Welcome to the MyeliNeuroGene (Bernard) Lab

The first Polr3b and 4H mouse model published in BRAIN

We are happy to announce the publication in Brain of our recent work developing and characterizing a mouse model of POLR3-related leukodystrophy. This is the first Polr3b mouse model and importantly, the first 4H mouse model to demonstrate widespread hypomyelination, motor defects, hypodontia and craniofacial features, all disease characteristics found in patients with POLR3-related leukodystrophy. 


We discovered that these mice had defects in the cells important for myelin production, the oligodendrocytes and their precursors. This model is an important to study POLR3-related leukodystrophy in more detail and to develop and test future therapeutics.


A big congratulations to Mack and the rest of the mouse team at the MyeliNeuroGene Lab for your amazing work. And thank you to our important collaborators, Dr. Trainor and his team at the Stowers Institute for Medical Research. 


This milestone achievement for 4H leukodystrophy research was made possible by generous funding from The Yaya Foundation for 4H Leukodystrophy, Leuco-Action, the Tallman Family, Fondation du Children - The Children's Foundation, Fonds de recherche du Québec, and Canadian Institutes of Health Research. Thank you to all! 


To read the full article: 


Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy


To read more about this news: 


Major scientific achievement gives hope to families affected by 4H leukodystrophy (MUHC News)


MUHC doctor's team reaches breakthrough against rare neurodegenerative disease (The Montreal Gazette)


Percée à McGill dans le traitement des leucodystrophies (La Press Canadienne)

Leukodystrophy Awareness Month (September 2023)

We asked research students at the McGill University Health Center Research Institute if they’ve ever heard about leukodystrophies for Leukodystrophy Awareness Month. 

Nous avons demandé aux étudiants en médecine de l’Université de Montréal s’ils avaient déjà entendu parler des leucodsytrophies pour le mois de la sensibilisation aux leucodystrophies.

The MyeliNeuroGene Lab had a great time at Dr. Bernard's house!

Dr. Bernard was awarded the Hugo Moser Service Award at the United Leukodystrophy Foundation conference.

This award recognizes the efforts of a medical professional who has greatly impacted the leukodystrophy community in patient care and research efforts. Dr. Bernard was recognized for her outstanding research in the field of hypomyelinating leukodystrophies, her exemplary patient care and tireless efforts working with the ULF and larger leukodystrophy community. 

The MyeliNeuroGene lab present at the 2023 United Leukodystrophy Foundation Family Conference!

Dr. Bernard was awarded the Pfizer Research Award of Excellence for her research done on pediatric hypomyelinating leukodystrophies!

Dr. Bernard is a Montreal Children's Hospital Foundation Champion!

The Montreal Children’s Hospital Foundation honours its “Champion” medical workers for the exceptional care and dedication they provide to their patients. 


Families can make a donation to the MCH Foundation to thank their “Champion” doctor, nurse or staff. Champions receive a certificate, a personalized message from the family, and a Champions Pin to wear proudly every day. 


Rare Disease day 2023

Neeti and Laura presenting at the Child Health and Human Development Research Day

September is Leukodystrophy Awareness Month! (2022)

Navy blue is the honourary colour of Leukodystrophy Awareness Month

Alex presenting her work on EPRS1-related leukodystrophies at the annual IPN Retreat

Congratulation to the now Dr. Stefanie Perrier on a successful PhD. Defense!

A HUGE THANK YOU to all our donors! Dr. Bernard and Luan at the Montreal Children's Hospital

Stef, Alex and Julia presented research on new gene discoveries and pathology at the annual Child Health and Human Development Conference

2021 Halloween at the Bernard Lab

Stef and Alex enjoying the United Leukodystrophy Foundation (ULF) #LickLeukodystrophy brain pops during Leukodystrophy awareness month (2021)

Lab members Alex and Stef presenting rare disease research with the RAREDIG Club (2019)

2018 conference on Current, Novel and Future Therapies

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